Meet our super hero Peyton! Peyton is six years old and is afflicted with Juvenile Metachromatic Leukodystrophy (MLD). Juvenile MLD is a type of metabolic lysosomal storage disease, which is commonly listed in the family of leukodystrophies as well as among the sphingolipidoses as it affects the metabolism of sphingolipids. MLD is directly caused by a deficiency of the enzyme arylsulfatase A.
Without this enzyme, sulfatides build up in tissues of the body, eventually destroying the myelin sheath of the nervous system. The myelin sheath is a fatty covering that protects nerve fibers. Without it, the nerves in the brain and the peripheral nerves which control things like your muscles, stop functioning.
Peyton had an umbilical cord stem cell transplant on September 7, 2011. The transplant was used in hopes to slow down progression of this terrible disease.