Rare Daily Staff
The University of Texas MD Anderson Cancer Center and the Broad Institute of MIT and Harvard launched a translational research platform to study rare cancers and develop a first-of-its-kind resource for the scientific community.
The joint initiative will create a catalog of rare cancer models and provide a data resource to accelerate the identification of therapeutics to treat patients diagnosed with rare tumor types.
The National Cancer Institute defines a rare cancer as one with fewer than 40,000 new cases per year. Cumulatively, rare cancers account for roughly one-quarter of all cancer cases and cancer deaths, but the low incidence of each different type of rare tumor presents a significant challenge to efforts to identify effective therapeutic approaches.
“Through this initiative, we hope to overcome some of the challenges that have prevented effective translational research in rare cancers,” said Timothy Heffernan, head of oncology research in MD Anderson’s Therapeutics Discovery division. “By collaborating with the Broad Institute, we have a tremendous opportunity to create a valuable resource for the entire scientific community that will inspire and catalyze a wave of innovative research to advance impactful new therapies to patients in need.”
MD Anderson is a leader in the diagnosis and treatment of rare cancers. It treats more than 5,000 patients with the rarest diagnoses seeking treatment annually. In 2019, MD Anderson established the Rare Tumor Initiative, a multidisciplinary effort to comprehensively characterize rare tumors throughout the course of each patients’ care. This new joint translational research platform builds upon MD Anderson’s existing commitment to rare cancers with the goal of enabling rapid translation of new therapeutic insights.
The new collaboration will generate models of rare tumors from MD Anderson patients at the Broad’s Cancer Cell Line Factory, which works to expand the number and variety (in terms of tumor types and cancer genotypes) of cancer models available for research. These models will be analyzed extensively by the Broad’s Cancer Dependency Map project, an effort to systematically detect genetic and pharmacologic vulnerabilities in cancer in order to identify molecular signatures that could inform novel therapeutic approaches.
The initiative aims to generate more than 100 rare cancer models, and to make those models and associated molecular data available to all members of the cancer research community.
“Treatments for rare cancers have lagged behind common tumors in large part because we as a community lack the tools to study and understand their unique biology in the laboratory,” explained William Sellers, director of the Broad’s Cancer Program. “This initiative represents a significant opportunity to close that gap and to start identifying new treatment options for patients with rare cancers.”
Photo: Timothy Heffernan, head of oncology research in MD Anderson’s Therapeutics Discovery division