Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia

ALSP, Hereditary diffuse leukoencephalopathy with spheroids

Overview

Type of disease: Rare Condition or Disease

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare progressive neurological condition characterized by changes to certain areas of the brain.

ALSP is one group of adult-onset leukodystrophy disorders.

Symptoms of ALSP usually begin in a person’s forties and worsen over time. Personality changes, including depression and a loss of social inhibitions, are among the earliest symptoms of ALSP. Over time, movement problems develop and include tremors, rigidity, slow movements, and problems sitting or standing. Because it can be mistaken for other disorders with similar symptoms, ALSP may be underdiagnosed. MRI can detect lesions in the brain and genetic testing for the CSF1R mutation can confirm an ALSP diagnosis.

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