Autosomal Dominant Partial Epilepsy with Auditory Features


Type of disease: Rare conditions

Autosomal dominant partial epilepsy with auditory features or ADPEAF, is a rare genetic disease caused by mutations in the LGI1 gene. The disease causes frequent seizures. A seizure occurs when the electrical signals in a person’s brain act irregularly. An individual with ADPEAF may show sound-related symptoms like buzzing, ringing, or humming. Sometimes a person may be unable to understand language and might fall unconscious. ADPEAF is a genetic disease that usually begins affecting individuals as children or young adults.

Autosomal dominant means the condition is inherited through genes (passed through families). We inherit our genes in pairs, one from each parent typically. Our genes are what control the growth, development and function of our bodies. If a mistake or error occurs in a gene, it can cause problems. If one parent has a mutation in LGI1, there a 50% chance of the child to have the mutation. Only 2/3 of those with the mutation will have seizures.

There are no known triggers for the seizures. Usually medicine from a doctor can help prevent seizures from occurring. Speak with your doctor about the best personal plan of action. There are many support groups like the Epilepsy Foundation to help with the condition.

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