Bruton Type Agammaglobulinemia

Overview

Type of disease: Rare conditions

Bruton type agammaglobulinemia is a form of agammaglobulinemia, an inherited disorder in which the body’s immune system cannot fight infectious diseases. This condition only affects males and causes recurrent bacterial infections during infancy or childhood. Signs and symptoms may include: skin infections, diarrhea, ear infections (otitis media), pinkeye (conjunctivitis), sinus infections (sinusitis), and respiratory infections. Lymph nodes and tonsils in affected patients are usually small or absent. The prevalence of this condition is between 1/350,000 people and 1/700,000 people, and can be inherited in both sporadic (random, meaning there is no previous family history and the mother is not a carrier), and x linked recessive pattern. This means that women who carry the changed gene which causes the condition will not have symptoms of the conditon but their sons will have a 50% chance of inheriting the changed gene and thus having the condition. Blood tests and examinations of family history can diagnose Bruton type agammaglobulinemia. There is no treatment for this condition, but it can be controlled through therapy and antibiotics.

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