Chronic infantile neurological cutaneous articular syndrome

CINCA, Infantile multisystem inflammatory disease, NOMID, Neonatal onset multisystem inflammatory disease


Type of disease: Rare conditions

Chronic infantile neurologic cutaneous and articular (CINCA) syndrome, also known as ‘neonatal onset multisystem inflammatory disease,’ or NOMID, is a congenital inflammatory disorder characterized by a triad of neonatal onset of cutaneous symptoms (skin rash), chronic meningitis, and joint pain with recurrent fever and inflammation.  CINCA is the most severe form of the cryopyrin associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NLRP3 gene. About 50% of affected individuals have mutations in this gene. This condition is inherited in an autosomal dominant fashion. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.

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