Cleft Lip Palate Pituitary Deficiency


Type of disease: Rare conditions

Cleft lip and/or palate pituitary deficiency is a genetic disorder describing the combination of cleft lip and underactivity of the anterior pituitary gland. The anterior pituitary is a small organ in the brain that is responsible for releasing hormones, or chemicals messengers, that stimulate growth. In addition to having an absent or underactive pituitary gland, the condition is characterized by the failure of the front part of the brain to develop into two halves, resulting in lack of olfactory bulbs (the part of the brain responsible for smell), facial abnormalities like cleft lip, and other brain defects. Children with cleft lip and/or palate pituitary deficiency are also at risk of multiple organ failure.

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