Type of disease: Rare conditions
Collagenous gastritis (CG) is a rare condition that primarily affects the gastrointestinal (GI) system. Individuals with CG have increased collagen deposition in the subepithelial layer of the stomach with infiltration of inflammatory cells in the gastric mucosa (mucous membrane layer of the stomach). This condition may affect children and young adults up to 22 years or older adults over 35 years of age; features appear to differ depending on the age group affected. Signs and symptoms in children and young adults often begin with anemia and abdominal pain, whereas older adults have loose stools frequently associated with collagenous colitis, celiac disease or both. The cause of the condition is unknown. There is currently no effective treatment. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.