Early Infantile Epileptic Encephalopathy

EIEE

Overview

Type of disease: Rare Condition or Disease

Early Infantile Epileptic Encephalopathy (EIEE) is a neurological disorder characterized by seizures. The disorder affects newborns, usually within the first three months of life (most often within the first 10 days) in the form of epileptic seizures. Infants have primarily tonic seizures (which cause stiffening of muscles of the body, generally those in the back, legs, and arms), but may also experience partial seizures, and rarely, myoclonic seizures (which cause jerks or twitches of the upper body, arms, or legs). Episodes may occur more than a hundred times per day. Most infants with the disorder show underdevelopment of part or all of the cerebral hemispheres or structural anomalies. Some cases are caused by metabolic disorders or by mutations in several different genes. The cause for many cases can’t be determined. There are several types of early infantile epileptic encephalopathy. The seizures associated with this disease are difficult to treat and the syndrome is severely progressive. Some children go on to develop other epileptic disorders such as West syndrome and Lennox-Gestaut syndrome. There is no cure for EIEE and patients require constant supervision and care.

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