Fibrolamellar carcinoma

Hepatocellular carcinoma (fibrolamellar variant)


Type of disease: Rare Condition or Disease

Fibrolamellar carcinoma is an uncommon malignant tumor that originates in the liver. This variant of hepatocellular carcinoma differs from conventional hepatocellular carcinoma in aetiology (cause), demographics, condition of the affected liver, and tumor markers.  This entity typically occurs in young adults (ages 20 to 40) with no underlying hepatitis or cirrhosis. In addition, the serum levels of alpha-fetoprotein are usually not elevated in patients with fibrolamellar hepatocellular carcinoma. Surgery is currently the most effective means of treating and controlling fibrolamellar variant cancer. While there is some debate about the issue, fibrolamellar variant carcinoma may have a better outlook (prognosis) than other forms of liver cancer. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.

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