Fox-Fordyce Disease

Overview

Type of disease: Rare conditions

Fox-Fordyce disease is a chronic skin disease most common in women aged 13-35 years.  It is characterized by the development of intense itching in the underarm area, the pubic area, and around the nipple of the breast as a result of  perspiration which becomes trapped in the sweat gland and surrounding areas.   The cause is unknown, but heat, humidity, and stress appear to be exacerbating factors. Retinoids, antibiotics, and immunosuppressants have had limited success in controlling the symptoms.  Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.

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