Howel-Evans syndrome

Tylosis with Esophageal Cancer


Type of disease: Rare conditions

Howel-Evans syndrome is an inherited condition characterized by palmoplantar keratoderma and esophageal cancer. The palmoplantar keratoderma usually begins around age 10, and esophageal cancer may form after age 20. This condition is thought to be caused by a mutation in an unidentified gene on chromosome 17. Howel-Evans syndrome has autosomal dominant inheritance. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.

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