Type of disease: Rare conditions
Huntington disease is a progressive disorder that causes brain cell (neuron) degeneration in certain areas of the brain. This results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. Symptoms typically appear between the ages of 35 and 44 years. People with Huntington disease most often live for 15 to 18 years after the condition appears. Huntington disease caused by mutations in the HTT gene and is inherited in an autosomal dominant manner. Each child of a person with Huntington disease has a 50 percent (1 in 2) chance of inheriting the mutation. There is also a less common, early-onset from that begins in childhood or adolescence, called juvenile Huntington disease. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.