Hyperaldosteronism, familial type 1

Dexamethasone-sensitive hypertension, FH-I, FH1, Familial hyperaldosteronism type 1, GRA, Glucocorticoid-sensitive hypertension

Overview

Type of disease: Rare conditions

Hyperaldosteronism, familial type 1 is a type of primary aldosteronism when the adrenal glands found above the kidneys release too much aldosterone.

Aldosterone is a hormone that helps keep sodium and potassium at proper levels in the body to regulate blood pressure. Overall, symptoms more commonly appear during childhood or early adulthood. Diagnosis of hyperaldosteronism, familial type 1 typically is discovered after experiencing heart problems or after testing the urine for hormone levels.

Hyperaldosteronism, familial type 1 is a genetic condition caused by a change (mutation) in the CYP11B2 and CYP11B1 genes. Genes are what control the growth, development, and function of the body. If a mistake or error occurs in a gene, this is called a mutation. Each person has two copies of every gene, one from the mother and one from the father. Hyperaldosteronism, familial type 1 is passed down from parent to child in an autosomal dominant manner, meaning only one mutation from one parent is inherited by a child in order to cause symptoms. A person with this condition has a 50/50 chance of passing the condition on to their children.

Hyperaldosteronism, familial type 1 is the most common type of secondary hypertension. This means that the high blood pressure has an underlying cause. Treatment includes small doses of medicine that help level the amount of hormones that adrenal glands produce. If you or a family member has been diagnosed with hyperaldosteronism, familial type 1, talk with your doctor about the most current treatment options as well as signs that you may need immediate medical attention.

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