ACAD8 deficiency, Isobutyryl-CoA dehydrogenase deficiency, IBG, IBD deficiency, Deficiency of isobutyryl-CoA dehydrogenase, Isobutyryl-coenzyme A dehydrogenase deficiency, Acyl-CoA dehydrogenase family – member 8
Type of disease: Rare Condition or Disease
Isobutyryl-CoA dehydrogenase deficiency (IBD deficiency) is an inborn error of valine (an amino acid) metabolism. The symptoms, which may not develop until later in infancy or childhood, can include failure to thrive, dilated cardiomyopathy, seizures, and anemia. IBD deficiency is caused by mutations in the ACAD8 gene. It is inherited in an autosomal recessive manner. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.