Progressive supranuclear palsy
Type of disease: Rare conditions
Progressive supranuclear palsy (PSP) is a movement disorder caused by damage to certain nerve cells in the brain. It affects brain cells that control the movement of the eyes. This leads to serious and permanent problems with balance and the way affected people walk. It usually occurs in middle-aged or elderly people. Symptoms are very different in each person, but may include personality changes; and speech, vision or swallowing problems. Doctors sometimes confuse PSP with Parkinson's disease or Alzheimer's disease. In most cases, the genetic cause of PSP is unknown. Rarely, the disease is known to result from mutations in the MAPT gene. PSP has no effective treatments, but some symptoms may be managed with medication. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.