Overview

Type of disease: Rare conditions

ROHHAD is an acronym for rapid-onset obesity (RO) with hypothalamic dysregulation (H), hypoventilation (H), and autonomic dysregulation (AD). It is a rare syndrome that affects the autonomic nervous system (the part of the nervous system that controls involuntary actions) and the endocrine system. As the name suggests, the most characteristic features include dramatic weight gain over a six- to 12-month period in the first 10 years of life followed by hypothalamic dysfunction, dysregulation of the autonomic nervous system, and alveolar hypoventilation. The exact underlying cause of ROHHAD is currently unknown. Treatment varies based on the signs and symptoms present in each person and the severity of the condition.Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.

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