Superior limbic keratoconjunctivitis


Type of disease: Rare conditions

Superior limbic keratoconjunctivitis (SLK) is a chronic and recurrent eye disease which affects the superior bulbar conjunctiva (the clear layer that covers the eyeball, over the sclera) and tarsal conjunctiva (the clear layer that lines the eyelids), as well as the superior limbic aspect of the cornea (the area above the cornea). It is commonly found in women 20-70 years of age. The signs and symptoms include burning, redness and irritation and tend to develop slowly over a period of 1 to 10 years.  Vision usually remains intact. While the underlying cause of SLK remains unknown, there appears to be an association between the condition and thyroid abnormalities (usually hyperthyroidism), contact lens wear, graft versus host disease, and preservatives from ophthalmologic medications.

Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.

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