Tropical calcific pancreatitis


Type of disease: Pediatric onset | Rare conditions

Tropical calcific pancreatitis, or TCP, is a genetic disorder of the pancreas. TCP is caused by a mutation (change) in one of the genes associated with the pancreas. In some individuals, this mutated gene cannot cause the disorder on its own. Rather, there needs to be a second mutation of the same gene or a mutation of a different gene in order for these individuals to have TCP. Abdominal pain normally starts when the individual is young, and the most common age of full onset of TCP is 21. TCP is often found in various tropical and developing countries.

Tropical calcific pancreatitis is not related to chronic pancreatitis from alcohol intake. TCP begins at an earlier age than chronic pancreatitis from alcohol intake, and TCP includes calcium buildup on the pancreas. Little stones between the ducts of the organ (intraductal calculi) are referred to as buildup. This leads to inflammation of the pancreas as well as chronic abdominal pain. In addition, there is a high incidence of an individual with TCP also having diabetes mellitus. Those with TCP have a higher chance of getting pancreatic cancer later in adulthood. If you or a family member has been diagnosed with tropical calcific pancreatitis, talk with your doctor about the most current treatment options. Support groups are also good resources of support and information.

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