Synonyms: APDS | Senescent T-cells-lymphadenopathy-immunodeficiency syndrome due to p110delta-activating mutation
A rare genetic primary immunodeficiency disease characterized by increased susceptibility to recurrent and/or severe bacterial and viral infections (in particular sinopulmonary bacterial and herpesvirus infections) chronic benign lymphoproliferation (manifesting as lymphadenopathy hepatosplenomegaly and focal nodular lymphoid hyperplasia) and/or autoimmune disease (including immune cytopenias juvenile arthritis glomerulonephritis and sclerosing cholangitis). Immunophenotypically variable degrees of agammaglobulinemia with increased IgM levels increased circulating transitional B cells decreased naïve CD4 and CD8 T-cells with increased CD8 effector/memory T cells are observed.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version May 2026
Newly diagnosed with
Activated PI3K-delta syndrome?
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Advocacy Organizations
APDS Rare Diesease Coalition
The APDS Rare Disease Coalition empowers patients and families affected by Activated PI3K Delta Syndrome through education, advocacy, and global support. We connect communities, promote awareness, encourage early diagnosis, and collaborate with medical and industry partners to improve care, resources, and hope for all impacted by APDS.
Immune Deficiency Foundation
To improve the diagnosis, treatment and quality of life of people affected by primary immunodeficiency.
Immunocompromised Association
Immunocompromised Association promotes awareness, education, and support for immunocompromised individuals to reduce their inherent health risks in the community.
No somos invisibles IDP – Perú
“No Somos Invisibles IDP Peru” is an initiative currently in the process of formal establishment that seeks to raise awareness of primary immunodeficiencies, promote timely access to diagnosis and treatment, and defend patients’ rights by fostering an informed, empathetic, and well-coordinated support network. Building visibility, access, and justice for every patient.
The AIP BIPOC Network
Our mission is to improve the quality of life of the BIPOC Autoimmune Community through Awareness, Advocacy, Action, Assessment and Access.
Uganda Alliance of Patients Organization
Supporting patients to access quality, safe and patient-centered healthcare services.
Ukrainian Association of Pediatric Immunology
Development of pediatric and clinical immunology in Ukraine. Raising awareness of inborn errors of immunity in Ukraine and rare immune diseases; Advocacy campaigns supporting patients with rare immune diseases and their treatment plans; Scientific research; Sharing knowledge about immunoprophylaxis; Advocacy campaigns supporting immunoprophylaxis.
accessia health
Accessia Health, a national charitable patient assistance organization, is dedicated to eliminating healthcare barriers for people with rare or chronic health conditions. Comprehensive services include personalized case management, financial assistance, education, and legal aid support. Our flexible funding model goes beyond copays, allowing individuals to pay for other essential medical expenses
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Clinical Trials
For a list of clinical trials in this disease area, please click here.