Acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor
Synonyms: AML and myelodysplastic syndromes related to topoisomerase type 2 inhibitor
A subgroup of therapy-related myeloid neoplasms (t-MN) associated with treatment of an unrelated neoplastic disease with cytotoxic agents like etoposid doxorubicin daunorubicin and others. The neoplastic cells often show rearrangements involving the mixed lineage leukemia gene at 11q23. This subgroup of t-MN is typically associated with overt leukemia without preceding myelodysplastic syndrome developing 2-3 years after exposure presenting with non-specific symptoms related to ineffective hematopoesis (fatigue bleeding and bruising recurrent infections bone pain) and/or extramedullary site involvement.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: //www.orphadata.org. Data version September 2023.
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