Acute poisoning by drugs with membrane-stabilizing effect

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Acute poisoning by drugs with membrane-stabilizing effect

A rare clinical situation characterized by acute potentially life-threatening toxic effects of drugs acting on voltage-gated sodium or calcium channels such as tricyclic antidepressants anticonvulsants local anesthetics and antiarrhythmics some beta-blockers and chloroquine. Clinical manifestations include abnormal ECG findings (intraventricular conduction block with widening of the QRS complex T wave flattening prolongation of the QT interval) and variable signs and symptoms depending on the drug typically involving the cardiovascular and central nervous system among others.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version December 2023

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