Adult-onset immunodeficiency with anti-interferon-gamma autoantibodies

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Synonyms: Acquired adult-onset immunodeficiency | Adult-onset immunodeficiency with acquired anti-interferon-gamma autoantibodies

A rare acquired immunodeficiency disorder characterized by the appearance of susceptibility to disseminated opportunistic infections (in particular disseminated nontuberculous mycobacterial infection salmonellosis penicillosis and varicella zoster virus infection) in previously healthy (HIV-negative) adults associated with the presence of acquired autoantibodies to interferon gamma. Typical clinical manifestation includes lymphadenopathy (cervical or generalized) fever weight loss and/or reactive skin lesions.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version June 2024

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