Aromatase excess syndrome

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Aromatase excess syndrome

Synonyms: AEXS | Familial hyperestrogenism | Hereditary prepubertal gynecomastia

A rare genetic endocrine disease characterized by increased levels of estrogen due to elevated extraglandular aromatase activity. Males present with heterosexual precocious puberty which manifests with pre- or peripubertal onset of gynecomastia premature growth spurt accelerated bone maturation resulting in decreased adult stature and may present mild hypogonadotropic hypogonadism. Female patients may have isosexual precocious puberty or not have any manifestations at all.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version February 2024

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