Autoimmune encephalopathy with parasomnia and obstructive sleep apnea

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Synonyms: Anti-IgLON5 disease | Anti-IgLON5 syndrome

A rare neurologic disorder characterized by a unique non-REM and REM parasomnia with sleep breathing dysfunction gait instability and repetitive episodes of respiratory insufficiency as well as autoantibodies against IgLON5. Patients may present stridor chorea limb ataxia abnormal ocular movements and bulbar symptoms (i.e. dysphagia dysarthria episodic central hypoventilation) with normal brain MRI. Excessive day sleepiness and cognitive deterioration have also been reported.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version July 2024

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Autoimmune encephalopathy with parasomnia and obstructive sleep apnea?

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Advocacy Organizations

Project CASK

VISION Project CASK believes in a world free of the life limitations and debilitating effects of CASK gene disorders. ​MISSION To accelerate breakthroughs in research to develop treatments and a cure for CASK gene disorders. ​VALUES Collaboration. Transparency. Urgency.

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Clinical Trials

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