Autosomal recessive myogenic arthrogryposis multiplex congenita

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Autosomal recessive myogenic arthrogryposis multiplex congenita

Synonyms: Autosomal recessive myogenic AMC | SYNE1-related AMC | SYNE1-related arthrogryposis multiplex congenita

Autosomal recessive myogenic arthrogryposis multiplex congenita is a rare inherited neuromuscular disease characterized by prenatal presentation (usually in the second trimester) of reduced fetal movements and abnormal positioning resulting in joint abnormalities that may involve both lower and upper extremities and is usually symmetric severe hypotonia at birth with bilateral club foot motor development delay mild facial weakness without opthalmoplegia absent deep tendon reflexes normal motor and sensory nerve conduction velocities no cerebellar or pyramidal involvement and progressive disease course with loss of ambulation after the first decade of life.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version March 2024

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Autosomal recessive myogenic arthrogryposis multiplex congenita?

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