Chilblain lupus
A rare chronic cutaneous lupus erythematosus disease characterized by red or violaceous initially pruritic (evolving to painful) papules and plaques located on acral areas (especially dorsal aspects of fingers and toes while the nose and ear involvement is uncommon) exacerbated by cold and damp conditions with fissuring and ulceration occasionally observed. Coexistence of discoid lupus erythematosus lesions elsewhere on the body and occasional progression to systemic lupus erythematosus may be associated. Histological examination and direct immunofluorescence studies reveal nonspecific inflammatory lupus erythematosus changes while results of cryoglobulin and cold agglutinin studies are negative.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Reference: Access aggregated data from Orphanet at Orphadata.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2024
Newly diagnosed with
Chilblain lupus?
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Advocacy Organizations
Syndromes Without A Name (SWAN) Australia
Provide information, support and advocacy to families caring for a child with an undiagnosed or rare genetic condition.
The Fairy Goddess Mother Project Inc.
The Fairy Goddess Mother Project is a 501(c)(3) Non-profit Rare Disease Patient Advocacy Organization dedicated to increasing awareness of the little-known, often misdiagnosed disease Vulvar Lichen Sclerosus (VLS), providing financial assistance to afflicted women in need of treatment, and supporting patients’ efforts to participate in clinical trials.
Clinical Trials
For a list of clinical trials in this disease area, please click here.