Chronic neutrophilic leukemia
A rare myeloproliferative neoplasm characterized by sustained peripheral blood neutrophilia bone marrow hypercellularity due to neutrophilic granulocyte proliferation and hepatosplenomegaly. Other organs may be infiltrated in addition. Microscopically the bone marrow shows an increase in proportion of myelocytes and mature neutrophils but no significant dysplasia in any of the cell lineages. Peripheral blood neutrophils are mostly segmented although band forms may also be substantially increased. Cytogenetic abnormalities are absent in most cases. The disease is slowly progressive with progredient neutrophilia followed by anemia and thrombocytopenia. Transformation to acute myeloid leukemia may occur.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Reference: Access aggregated data from Orphanet at Orphadata.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2024
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