Diethylstilbestrol syndrome

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Synonyms: DES embryofetopathy | DES syndrome | Diethylstilbestrol embryofetopathy | Distilbene embryofetopathy

A malformation syndrome reported in offspring (children and grandchildren) of women exposed to diethylstilbestrol (DES) during pregnancy and is characterized by reproductive tract malformations decreased fertility and increased risk of developing clear cell carcinoma of the vagina and cervix in young women. Reproductive malformations reported in DES syndrome include small T-shaped uteri and other uterotubal anomalies that increase the risk of miscarriages in women and epididymal cysts microphallus cryptorchidism or testicular hypoplasia in men. DES a synthetic nonsteroidal estrogen was widely prescribed from 1940-1970 to prevent miscarriage.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version May 2024

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