Diffuse leptomeningeal melanocytosis
Synonyms: DLM | Leptomeningeal melanomatosis
Diffuse leptomeningeal melanocytosis is a rare tumor of meninges arising from leptomeningeal melanocytes characterized by diffuse infiltration of the leptomeninges (pia mater and arachnoidea) anywhere in the central nervous system. Clinical features may include stillbirth intracranial hypertension and hydrocephalus seizure ataxia syringomyelia cranial nerve palsy intracranial haemorrhage sphincter dysfunction and neuropsychiatric symptoms. Transformation into malignant melanoma of the central nervous system was reported. It may be associated with congenital nevi as a part of neurocutaneous melanosis.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version December 2023
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Diffuse leptomeningeal melanocytosis?
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