Dowling-Degos disease

Get in touch with RARE Concierge.

Contact RARE Concierge

Synonyms: Reticular pigment anomaly of flexures

A rare genetic hyperpigmentation of the skin disease characterized by adulthood-onset of reticular reddish-brown to dark-brown macular and/or comedone-like hyperkeratotic papules with hypopigmented macules predominantly affecting flexural areas and on occasion progressing to involve trunk and acral regions. Histologically epidermal acanthosis thin branch-like rete ridges and a tendency for acantholysis and pigmentary incontinence is observed.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version June 2024

Newly diagnosed with
Dowling-Degos disease?

Our RARE Concierge Services Guides are available to assist you by providing information, resources and connections as you navigate your rare disease journey.

Get Concierge Help

Advocacy Organizations


Our mission is to promote greater awareness and understanding of CDG & NGLY1-Deficiency, to provide information and support to families affected by CDG & NGLY1, and to advocate for and fund scientific research to advance the diagnosis and treatment of CDG & NGLY1-Deficiency.

Don't see your organization here. Let us know here.

Clinical Trials

For a list of clinical trials in this disease area, please click here.