Dowling-Degos disease

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Dowling-Degos disease

Synonyms: Reticular pigment anomaly of flexures

A rare genetic hyperpigmentation of the skin disease characterized by adulthood-onset of reticular reddish-brown to dark-brown macular and/or comedone-like hyperkeratotic papules with hypopigmented macules predominantly affecting flexural areas and on occasion progressing to involve trunk and acral regions. Histologically epidermal acanthosis thin branch-like rete ridges and a tendency for acantholysis and pigmentary incontinence is observed.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version March 2024

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Dowling-Degos disease?

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Advocacy Organizations

CDG CARE

Our mission is to promote greater awareness and understanding of CDG & NGLY1-Deficiency, to provide information and support to families affected by CDG & NGLY1, and to advocate for and fund scientific research to advance the diagnosis and treatment of CDG & NGLY1-Deficiency.

Mississippi Metabolics Foundation

Mississippi Metabolics Foundation (MMF) was founded to raise awareness, educate, and provide support to those living or caring for someone with genetic metabolic disorders/inborn errors of metabolism (IEM).

Clinical Trials

For a list of clinical trials in this disease area, please click here.