Duplication of the pituitary gland
Synonyms: DPG-plus syndrome | Duplication of the pituitary gland-plus syndrome | Hypophyseal duplication
A rare midline cerebral malformation characterized by duplicated pituitary stalks and/or glands within duplicated sella. Patients may present various degrees of facial dysmorphism and endocrine abnormalities including precocious puberty hypogonadism hypothyroidism and/or hyperprolactinemia as well as associated congenital anomalies such as clift lip/palate bifid nasal bridge/tongue/uvula hypothalamic enlargement with or without hamartoma nasopharyngeal tumors corpus callosum agenesis/hypoplasia basilar artery duplication and/or vertebral defects (in particular duplication of the odontoid process).
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Reference: Access aggregated data from Orphanet at Orphadata.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version March 2024
Newly diagnosed with
Duplication of the pituitary gland?
Our RARE Concierge Services Guides are available to assist you by providing information, resources and connections as you navigate your rare disease journey.
Advocacy Organizations
COMBINEDBrain Inc
COMBINEDBrain is a consortium for outcome measures and biomarkers for neurodevelopmental disorders. We are collaborating to cure rare, non-verbal brain disorders.
Moonshots for Unicorns
Curing single-gene disorders
Project CASK
To fund research for treatment and/or a cure for CASK Gene Disorder
Syndromes Without A Name (SWAN) Australia
Provide information, support and advocacy to families caring for a child with an undiagnosed or rare genetic condition.
Clinical Trials
For a list of clinical trials in this disease area, please click here.