Giant cell tumor of bone

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Giant cell tumor of bone

Synonyms: GCT of bone | Osteoclastoma

A rare bone sarcoma characterized by a usually benign space-occupying lesion which is nevertheless locally aggressive and massively damaging to surrounding bone tissue. The tumor is composed of giant multinucleated cells (osteoclast-like cells) mononuclear macrophages and mononuclear stromal cells which secrete pro-myeloid and pro-osteoclastic factors. Metastasis and malignant transformation are rare but the recurrence rate is high.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: // Data version September 2023.

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