Hereditary diffuse gastric cancer
Synonyms: FDGC | Familial diffuse cancer of stomach | Familial diffuse gastric cancer | HDGC | Hereditary diffuse cancer of stomach | Hereditary diffuse gastric adenocarcinoma
Hereditary diffuse gastric cancer is a rare epithelial tumor of the stomach characterized by the development of diffuse (signet ring cell) gastric cancer at a young age associated with germline heterozygous mutations of CDH1 MAP3K6 and CTNNA1 genes. In early stages it presents with non-specific and vague symptoms in advanced stages it may cause nausea and vomiting dysphagia loss of appetite abdominal mass or weight loss. Women have an increased risk of lobular breast cancer as well.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Reference: Access aggregated data from Orphanet at Orphadata.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2024
Newly diagnosed with
Hereditary diffuse gastric cancer?
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Advocacy Organizations
Help Hope Live
Help Hope Live assists individuals living with catastrophic injuries and illnesses to fundraise toward their medical expenses and related costs.
My Faulty Gene
My Faulty Gene is a nonprofit organization which provides information and assistance to any individual whose family medical history suggests genetic testing might be helpful in identifying an increased risk of disease due to a genetic mutation. We believe that everyone in need of genetic testing should have access to it.
My Little Sunshine Foundation
My Little Sunshine is a non-profit foundation dedicated to educating people about the importance of fertility preservation and making fertility resources accessible to all.
SALUS
Educate and provide resources to POC with Rare Cancers
Syndromes Without A Name (SWAN) Australia
Provide information, support and advocacy to families caring for a child with an undiagnosed or rare genetic condition.
Clinical Trials
For a list of clinical trials in this disease area, please click here.