Hereditary diffuse gastric cancer

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Hereditary diffuse gastric cancer

Synonyms: FDGC | Familial diffuse cancer of stomach | Familial diffuse gastric cancer | HDGC | Hereditary diffuse cancer of stomach | Hereditary diffuse gastric adenocarcinoma

Hereditary diffuse gastric cancer is a rare epithelial tumor of the stomach characterized by the development of diffuse (signet ring cell) gastric cancer at a young age associated with germline heterozygous mutations of CDH1 MAP3K6 and CTNNA1 genes. In early stages it presents with non-specific and vague symptoms in advanced stages it may cause nausea and vomiting dysphagia loss of appetite abdominal mass or weight loss. Women have an increased risk of lobular breast cancer as well.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version March 2024

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Clinical Trials

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