Hereditary diffuse gastric cancer

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Synonyms: FDGC | Familial diffuse cancer of stomach | Familial diffuse gastric cancer | HDGC | Hereditary diffuse cancer of stomach | Hereditary diffuse gastric adenocarcinoma

Hereditary diffuse gastric cancer is a rare epithelial tumor of the stomach characterized by the development of diffuse (signet ring cell) gastric cancer at a young age associated with germline heterozygous mutations of CDH1 MAP3K6 and CTNNA1 genes. In early stages it presents with non-specific and vague symptoms in advanced stages it may cause nausea and vomiting dysphagia loss of appetite abdominal mass or weight loss. Women have an increased risk of lobular breast cancer as well.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version July 2024

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Advocacy Organizations

Help Hope Live

Help Hope Live supports community-based fundraising for people with unmet medical expenses and related costs due to cell and organ transplants or catastrophic injuries and illnesses. These efforts play a critical role in helping clients access the care and equipment they need to heal, live, and thrive. Unlock a powerful and safe way to raise funds for medical needs with Help Hope Live. They provide one-on-one fundraising guidance, a customizable Campaign Page, bill pay support, and additional benefits based on their 501(c)(3) nonprofit status.

My Faulty Gene

My Faulty Gene is a nonprofit organization which provides information and assistance to any individual whose family medical history suggests genetic testing might be helpful in identifying an increased risk of disease due to a genetic mutation. We believe that everyone in need of genetic testing should have access to it.

My Little Sunshine Foundation

My Little Sunshine is a non-profit foundation dedicated to educating people about the importance of fertility preservation and making fertility resources accessible to all.


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Clinical Trials

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