High-grade neuroendocrine carcinoma of the corpus uteri

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Synonyms: High-grade neuroendocrine carcinoma of the uterine corpus | Poorly differentiated neuroendocrine carcinoma of the corpus uteri | Poorly differentiated neuroendocrine carcinoma of the endometrium

High-grade neuroendocrine carcinoma of the corpus uteri is an extremely rare aggressive primary uterine neoplasm originating from neuroendocrine cells scattered within the endometrium characterized macroscopically by a bulky frequently polypoid mass with abundant necrosis located in the uterus and histologically by rosette-like and cord-like structures consisting of small rounded cells with oval nuclei and scarce cytoplasm. Patients often present with dysfunctional uterine bleeding pelvic or abdominal mass and especially in later stages of the disease abdominal pain. Symptomatic metastatic spread or symptoms related to a paraneoplastic syndrome such as retinopathy or Cushing syndrome due to ectopic ACTH production may be associated.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version June 2024

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