Hyperkeratosis lenticularis perstans

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Synonyms: Flegel disease

A rare skin disease characterized by usually asymptomatic hyperkeratotic reddish-brown papules primarily located on the lower extremities. Histological examination shows lamellar hyperkeratosis with abrupt peripheral basket-weave orthokeratosis irregular acanthosis and underlying lichenoid lymphocytic infiltrate. The condition may be sporadic or familial.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version June 2024

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Hyperkeratosis lenticularis perstans?

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Clinical Trials

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