Isolated focal non-epidermolytic palmoplantar keratoderma

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A rare hereditary palmoplantar keratoderma characterized by focal hyperkeratotic lesions on the palms and soles. Histopathologic examination reveals prominent hyperkeratosis thickened stratum spinosum with reduced stratum granulosum disadhesion of cells in the suprabasal layers elongation of rete ridges and sparse lymphocyte infiltration in the dermis.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on Data version July 2024

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Isolated focal non-epidermolytic palmoplantar keratoderma?

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