Lower motor neuron syndrome with late-adult onset

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Synonyms: LOSMoN | Late-onset spinal motor neuronopathy | SMAJ | Spinal muscular atrophy, Jokela type

A rare genetic motor neuron disease characterized by slowly progressive predominantly proximal muscular weakness and atrophy which typically manifests with muscle cramps fasciculations decreased/absent deep tendon reflexes hand tremor and elevated serum creatine kinase at onset and later associates with reduced walking ability and impaired vibration sensation.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version July 2024

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Lower motor neuron syndrome with late-adult onset?

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Advocacy Organizations

Association Aux Pas du Coeur – Côte d’ivoire

Our organization wants to raise awareness and recognition of rare diseases in Ivory Coast. Our mission is to: Raise awareness and campaign to help with the diagnosis and free therapeutic care of patients. Request and/or contribute to actions relating to the training of the medical profession to be able to make a final diagnosis and ensure continuous monitoring of patients easily.

Friends of Be an Angel

To support Ukrainian refugees and rescue efforts. We provide humanitarian aid, medical evacuations and mental health education programs for the Ukrainian people suffering from the full-scale invasion. Join us to provide a future for those most vulnerable.

Project CASK

VISION Project CASK believes in a world free of the life limitations and debilitating effects of CASK gene disorders. ​MISSION To accelerate breakthroughs in research to develop treatments and a cure for CASK gene disorders. ​VALUES Collaboration. Transparency. Urgency.

SMA Philippines Organization Inc.

Driven by the belief that no one gets left behind, we are dedicated to enhancing the lives of individuals affected with spinal muscular atrophy (SMA) through advocacy, education, and support. Our goal is to raise awareness, improve access to essential care and resources, advocate for equitable treatment opportunities, and champion the rights of individuals with SMA.

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Clinical Trials

For a list of clinical trials in this disease area, please click here.