Methotrexate toxicity

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Methotrexate toxicity

A rare intoxication characterized by acute renal tubular toxicity due to crystallization of methotrexate in the renal tubular lumen (which in turn leads to impaired methotrexate clearance and further deterioration of renal function and exacerbation of non-renal adverse events) myelosuppression with pancytopenia gastrointestinal mucositis maculopapular skin rash chemical conjunctivitis hepatotoxicity (reversible chemical hepatitis and hyperbilirubinemia) pulmonary toxicity and in severe cases multiorgan failure. Central nervous system involvement including headaches seizures and stroke-like symptoms may also be observed.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: // Data version September 2023.

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