Mixed phenotype acute leukemia

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Synonyms: MPAL

A group of rare acute leukemias of ambiguous lineage characterized by the presence of separate populations of blasts of more than one lineage (bilineal) a single population of blasts coexpressing antigens of more than one lineage (biphenotypic) or a combination thereof. The diagnosis relies on immunophenotyping the T-cell component being characterized by strong expression of cytoplasmic CD3 usually in the absence of surface CD3 the B-cell component expressing CD19 almost always together with CD10 cCD79a CD22 or PAX5 while the most specific hallmark of the myeloid component is the presence of myeloperoxidase in the blast cytoplasm.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version July 2024

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Mixed phenotype acute leukemia?

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Advocacy Organizations

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A Community for Telomere Biology Disorders Our mission is to provide information and support services to families worldwide affected by Dyskeratosis Congenita and Telomere Biology Disorders, to encourage the medical community’s research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

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Clinical Trials

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