Myeloid/lymphoid neoplasm associated with FGFR1 rearrangement

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Myeloid/lymphoid neoplasm associated with FGFR1 rearrangement

Synonyms: 8p11 myeloproliferative syndrome | Stem cell leukemia/lymphoma

A rare malignant neoplastic disease characterized by clonal proliferation of myeloid and/or lymphoid precursors harboring translocations or insertions involving the chromosome band 8p11 and the FGFR1 gene in the blood bone marrow and often other tissues as well (spleen liver lymph nodes breast etc.). It usually presents as myeloproliferative neoplasm with eosinophilia T lymphoblastic lymphoma with eosinophilia or less frequently acute myeloid leukemia. The presenting signs and symptoms include eosinophilia leukocytosis with leukemoid reaction monocytosis fatigue sweating weight loss lymphadenopathy splenomegaly and/or hepatomegaly. Extranodal involvement may include the tonsils lungs and breasts.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: // Data version September 2023.

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Advocacy Organizations

Youth and Women for Opportunities Uganda-YWOU

Youth and Women for Opportunities-YWOU an organization that we represent is patient organization re-presentative, patient and institution and individual capacity builder supporting PLWRD’s to obtain diagnosis, treatment and drugs for those suffering consequences of being undiagnosed or misdiagnosed and lack treatment and those who lack precise diagnosis for rare, orphan and undiagnosed diseases preventing PLWRD’s accessing the most adapted care, treatment or surgery, have delayed access to the most appropriate care, treatment or surgery

My Faulty Gene

My Faulty Gene is a nonprofit organization which provides information and assistance to any individual whose family medical history suggests genetic testing might be helpful in identifying an increased risk of disease due to a genetic mutation. We believe that everyone in need of genetic testing should have access to it.

My Little Sunshine Foundation

My Little Sunshine is a non-profit foundation dedicated to educating people about the importance of fertility preservation and making fertility resources accessible to all.


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