Myeloid/lymphoid neoplasm associated with FGFR1 rearrangement
Synonyms: 8p11 myeloproliferative syndrome | Stem cell leukemia/lymphoma
A rare malignant neoplastic disease characterized by clonal proliferation of myeloid and/or lymphoid precursors harboring translocations or insertions involving the chromosome band 8p11 and the FGFR1 gene in the blood bone marrow and often other tissues as well (spleen liver lymph nodes breast etc.). It usually presents as myeloproliferative neoplasm with eosinophilia T lymphoblastic lymphoma with eosinophilia or less frequently acute myeloid leukemia. The presenting signs and symptoms include eosinophilia leukocytosis with leukemoid reaction monocytosis fatigue sweating weight loss lymphadenopathy splenomegaly and/or hepatomegaly. Extranodal involvement may include the tonsils lungs and breasts.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: //www.orphadata.org. Data version September 2023.
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Myeloid/lymphoid neoplasm associated with FGFR1 rearrangement?
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