Myeloid/lymphoid neoplasm associated with FGFR1 rearrangement
Synonyms: 8p11 myeloproliferative syndrome | Stem cell leukemia/lymphoma
A rare malignant neoplastic disease characterized by clonal proliferation of myeloid and/or lymphoid precursors harboring translocations or insertions involving the chromosome band 8p11 and the FGFR1 gene in the blood bone marrow and often other tissues as well (spleen liver lymph nodes breast etc.). It usually presents as myeloproliferative neoplasm with eosinophilia T lymphoblastic lymphoma with eosinophilia or less frequently acute myeloid leukemia. The presenting signs and symptoms include eosinophilia leukocytosis with leukemoid reaction monocytosis fatigue sweating weight loss lymphadenopathy splenomegaly and/or hepatomegaly. Extranodal involvement may include the tonsils lungs and breasts.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.
Reference: Access aggregated data from Orphanet at Orphadata.
Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2024
Newly diagnosed with
Myeloid/lymphoid neoplasm associated with FGFR1 rearrangement?
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Advocacy Organizations
Care-for-Rare America Inc
To establish a global alliance in order to identify the genetic causes of rare diseases and develop effective treatments, following a three-stage approach: recognize, understand, cure.
Help Hope Live
Help Hope Live assists individuals living with catastrophic injuries and illnesses to fundraise toward their medical expenses and related costs.
My Faulty Gene
My Faulty Gene is a nonprofit organization which provides information and assistance to any individual whose family medical history suggests genetic testing might be helpful in identifying an increased risk of disease due to a genetic mutation. We believe that everyone in need of genetic testing should have access to it.
My Little Sunshine Foundation
My Little Sunshine is a non-profit foundation dedicated to educating people about the importance of fertility preservation and making fertility resources accessible to all.
SALUS
Educate and provide resources to POC with Rare Cancers
Youth And Women for Opportunities Uganda-YWOU
Our mission supports Rare, orphan and undiagnosed diseases diagnosis, care and treatment, education, awareness and empowering health care professionals and patients care takers of rare, orphan and undiagnosed diseases arena in Uganda, build capacity and bridge lack of clinical knowledge and experience and provide search/quest for diagnostic laboratories, I advocate for changes in laws, practices
Clinical Trials
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