Primary cutaneous diffuse large B-cell lymphoma, leg type

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Synonyms: PCDLBCL,LT

A rare aggressive primary cutaneous B-cell lymphoma characterized by rapidly progressive red to bluish often ulcerating nodular tumors predominantly involving the lower legs. Histology shows sheets of centroblasts and immunoblasts that spare the epidermis but infiltrate the dermis and subcutaneous tissues and often disseminate extracutaneously. The neoplastic cells typically express CD20 CD79a Bcl-2 MUM-1 and FOXP1 but are negative for CD10.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version May 2024

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Primary cutaneous diffuse large B-cell lymphoma, leg type?

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Advocacy Organizations

Cutaneous Lymphoma Foundation

Judy Jones, Judith Shea, and Dr. Stuart Lessin, frustrated with the lack of reliable information about cutaneous lymphomas, started the Mycosis Fungoides Foundation (now the Cutaneous Lymphoma Foundation) in 1998 The Cutaneous Lymphoma Foundation is an independent, non-profit patient advocacy organization dedicated to supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

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Clinical Trials

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