Primary cutaneous marginal zone B-cell lymphoma

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Primary cutaneous marginal zone B-cell lymphoma

Synonyms: PCMZL

A rare indolent primary cutaneous B-cell lymphoma characterized by multifocal red to violaceous papules plaques or nodules localized predominantly on the trunk and extremities. Histologically these are dermis infiltrates consisting of small marginal zone B cells lymphoplasmacytic cells and plasma cells. Marginal zone B cells express CD20 CD79a and Bcl-2 and are negative for CD5 CD10 and Bcl-6. Plasma cells are typically located at the periphery and express CD138 CD79a and monotypic light chains.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version February 2024

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Primary cutaneous marginal zone B-cell lymphoma?

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Advocacy Organizations

Cutaneous Lymphoma Foundation

Judy Jones, Judith Shea, and Dr. Stuart Lessin, frustrated with the lack of reliable information about cutaneous lymphomas, started the Mycosis Fungoides Foundation (now the Cutaneous Lymphoma Foundation) in 1998 The Cutaneous Lymphoma Foundation is an independent, non-profit patient advocacy organization dedicated to supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Clinical Trials

For a list of clinical trials in this disease area, please click here.