Systemic monochloroacetate poisoning

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Systemic monochloroacetate poisoning

Systemic monochloroacetate poisoning is a rare life-threatening intoxication with monochloroacetic acid (mainly through the skin but also by inhalation or ingestion). It is characterized by vomiting diarrhea and central nervous system (CNS)-excitability (disorientation delirium convulsions) as early signs of systemic poisoning followed by CNS-depression coma and cerebral edema. Additional signs include heart involvement (severe myocardial depression shock arrhythmias nonspecific myocardial damage) severe metabolic acidosis hypokalemia hypocalcemia and progressive renal failure leading to anuria. Myoglobinemia and leukocytosis may occur. Manifestations may be delayed for 1-4 hours.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: // Data version September 2023.

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