Transient myeloproliferative syndrome

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Transient myeloproliferative syndrome

Synonyms: TMD | Transient abnormal myelopoiesis | Transient myeloproliferative disease

A rare hematologic disease characterized by clinical and morphological findings indistinguishable from those of acute myeloid leukemia typically occurring in newborns with Down syndrome. Peripheral blood and bone marrow blasts display features suggestive of megakaryoblasts. In addition to trisomy 21 acquired GATA1 mutations are present in blast cells. Patients may be asymptomatic or present with thrombocytopenia less commonly other cytopenias leukocytosis hepatosplenomegaly jaundice ascites respiratory distress bleeding and pericardial or pleural effusions. Most patients undergo spontaneous remission within the first three months of life although some may develop life-threatening hepatic renal or cardiac complications.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version March 2024

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Transient myeloproliferative syndrome?

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Advocacy Organizations

My Faulty Gene

My Faulty Gene is a nonprofit organization which provides information and assistance to any individual whose family medical history suggests genetic testing might be helpful in identifying an increased risk of disease due to a genetic mutation. We believe that everyone in need of genetic testing should have access to it.

My Little Sunshine Foundation

My Little Sunshine is a non-profit foundation dedicated to educating people about the importance of fertility preservation and making fertility resources accessible to all.

SALUS

Educate and provide resources to POC with Rare Cancers

Youth And Women for Opportunities Uganda-YWOU

Our mission supports Rare, orphan and undiagnosed diseases diagnosis, care and treatment, education, awareness and empowering health care professionals and patients care takers of rare, orphan and undiagnosed diseases arena in Uganda, build capacity and bridge lack of clinical knowledge and experience and provide search/quest for diagnostic laboratories, I advocate for changes in laws, practices

Clinical Trials

For a list of clinical trials in this disease area, please click here.