Tropical spastic paraparesis

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Synonyms: HAM/TSP | HTLV-1-associated myelopathy/tropical spastic paraparesis | Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis | Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis | TSP

Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy more frequently reported in women than in men that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs bladder and bowel dysfunction and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version September 2024

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Advocacy Organizations

Project CASK

VISION Project CASK believes in a world free of the life limitations and debilitating effects of CASK gene disorders. ​MISSION To accelerate breakthroughs in research to develop treatments and a cure for CASK gene disorders. ​VALUES Collaboration. Transparency. Urgency.

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Clinical Trials

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