Vitamin K antagonist embryofetopathy
Synonyms: Vitamin K antagonist embryopathy | Warfarin embryofetopathy | Warfarin embryopathy | di Sala syndrome
Vitamin K antagonist embryofetopathy is characterized by a group of symptoms that may be observed in a fetus or newborn when the mother has taken oral vitamin K antagonists such as warfarin during pregnancy. Vitamin K antagonists are anticoagulant drugs that provide efficient thromboprophylaxis and that can cross the placenta. 5-12 % of infants exposed to warfarin between 6-9 weeks gestation present nasal hypoplasia and skeletal abnormalities including short limbs and digits (brachydactyly) and stippled epiphyses. Warfarin fetopathy with central nervous system abnormalities (hydrocephalus intellectual disability spasticity and hypotonia) or ocular abnormalities (microphthalmia cataract optic atrophy) fetal loss and stillbirth occurs in infants exposed at later gestations. Additional features that have been reported after in utero warfarin exposure include facial dysmorphism (cleft lip and/or palate malformed ears) choanal atresia or stenosis aorta coarctation situs inversus totalis bilobed lungs and ventral midline dysplasia.
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Vitamin K antagonist embryofetopathy?
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Center for Chronic Illness
The Center for Chronic Illness (CCI) promotes well-being and decreases isolation for those impacted by ongoing health challenges through support and education.
TO INCLUDE, INFORM AND INSPIRE people around the globe through the joy of skating, reflecting the compassion, respect and innovation that make ours the world’s premier inclusive organisation. Inclusive Skating is dedicated to the advancement of public participation in sport and the promotion of equality and diversity. Our primary objective is the development and implementation of programming which fosters the inclusion of skaters with any form of impairment or disability. Our ethos of inclusion extends to skaters of all ages and backgrounds; we welcome all with open arms. Values of empathy, integrity and empowerment are central to the pursuit of these goals. We believe that everyone should have the opportunity to experience the community, camaraderie, self-fulfilment, achievement, challenge, and thrill that participation in skating sports offers. We work to create these opportunities by offering activities, educational resources, events, training, and championships for our community.
Rare Disease Ghana Initiative
To improve the wellbeing and quality of life of persons living with undiagnosed and rare diseases in Ghana
Connecting young adults impacted by a rare or chronic condition with social and emotional support in the hope of improving their quality of life.
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Patient Advocate Foundation
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Botswana Organisation for rare Diseases
advocate for Rare disease patients and their families
Life Branches NFP Inc
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Youth and Women for Opportunities Uganda-YWOU
Youth and Women for Opportunities-YWOU an organization that we represent is patient organization re-presentative, patient and institution and individual capacity builder supporting PLWRD’s to obtain diagnosis, treatment and drugs for those suffering consequences of being undiagnosed or misdiagnosed and lack treatment and those who lack precise diagnosis for rare, orphan and undiagnosed diseases preventing PLWRD’s accessing the most adapted care, treatment or surgery, have delayed access to the most appropriate care, treatment or surgery
Indo US Organization for Rare Diseases (IndoUSrare)
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Inspire Medical Communications, LCC
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For a list of clinical trials in this disease area, please click here.