Progressive supranuclear palsy-progressive non-fluent aphasia syndrome

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Progressive supranuclear palsy-progressive non-fluent aphasia syndrome

Synonyms: PSP-AOS | PSP-PNFA | Progressive supranuclear palsy-apraxia of speech syndrome

An atypical variant of progressive supranuclear palsy (PSP) a rare late-onset neurodegenerative disease characterized by an initial presentation of an isolated speech and language disorder (apraxia of speech agrammatism and phonemic errors) years before developing other motor features of PSP. Neuropathological characteristics includes tau pathology and neuronal loss in specific brain areas especially in the temporal cortex and superior frontal gyrus.

Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview.

Reference: Access aggregated data from Orphanet at Orphadata.

Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http: //www.orphadata.org. Data version September 2023.

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Advocacy Organizations

Genetic Support Network of Victoria

The Genetic Support Network of Victoria is an organisation that supports people living with genetic, undiagnosed and rare conditions and those who support them including community and families, patient support organisations, health professionals and industry. Our vision is our community flourishing and living their best lives.

Clinical Trials

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