A rare low-grade astrocytoma characterized by a high degree of cellular differentiation slow growth and diffuse infiltration of adjacent brain structures and corresponding to WHO grade II. The tumor typically affects young adults and has an intrinsic tendency for progression to high-grade glioma. Histological variants are fibrillary gemistocytic and protoplasmic astrocytoma. Patients most commonly present with seizures but also with other neurological or neuropsychological abnormalities depending on the location.
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version May 2026
Newly diagnosed with
Diffuse astrocytoma?
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Advocacy Organizations
Pediatric Brain Tumor Foundation
Since 1991, the Pediatric Brain Tumor Foundation has led in funding research, supporting families, and advocating for policies to help patients and survivors. As the largest patient advocacy funder, it drives vital discoveries, new trials, and better treatments. Guided by patient and family experiences, PBTF supports families’ needs at every stage, focusing on care of the entire family.
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Clinical Trials
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