Synonyms: HGPS | Progeria
Hutchinson-Gilford progeria syndrome is a rare fatal autosomal dominant and premature aging disease beginning in childhood and characterized by growth reduction failure to thrive a typical facial appearance (prominent forehead protuberant eyes thin nose with a beaked tip thin lips micrognathia and protruding ears) and distinct dermatologic features (generalized alopecia aged-looking skin sclerotic and dimpled skin over the abdomen and extremities prominent cutaneous vasculature dyspigmentation nail hypoplasia and loss of subcutaneous fat).
Data from Orphanet are used to provide information on a disease's name, synonym(s), and overview. Reference: Access aggregated data from Orphanet at Orphadata. Orphadata: Free access data from Orphanet. © INSERM 1999. Available on http://www.orphadata.org. Data version April 2026
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Hutchinson-Gilford progeria syndrome?
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Advocacy Organizations
The Chandler Project
The Chandler Project brings awareness and shines a light on transformative research surrounding achondroplasia and other skeletal dysplasias by offering support to a global community and network of patients, parents, and caregivers seeking information on scientific discoveries, pharmaceutical advancements and surgical treatment options.
Wave of Support, Inc
Empowering those affected by bleeding disorders and other rare disease through advocacy, resources, education, and support
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Clinical Trials
For a list of clinical trials in this disease area, please click here.